Persistence of HIV-1 transmitted drug resistance mutations

TitlePersistence of HIV-1 transmitted drug resistance mutations
Publication TypeJournal Article
Year of Publication2013
AuthorsCastro H, Pillay D, Cane P A, Asboe D, Cambiano V, Phillips AN, Dunn DT
JournalJ Infect Dis
Volume208
Pagination1459-63
Date Published2013-11
ISBN Number0022-1899
Accession Number23904291
KeywordsAdolescent, Adult, Anti-HIV Agents/*pharmacology/therapeutic use, Drug Resistance, Viral/*genetics, Female, HIV Infections/drug therapy/*virology, Hiv-1, HIV-1/drug effects/*genetics, Humans, Male, mutations, persistence, resistance, transmitted, Young Adult
Abstract

There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models.

Short TitleThe Journal of infectious diseases
Alternate JournalThe Journal of infectious diseases