The UK HIV Drug Resistance Database was a central repository for resistance tests performed as part of routine clinical care throughout the UK between 2001 and 2019. By the end of 2019 over 165,000 test results, most in the form of viral gene sequences, had been received and curated.

A key feature of the Database was extensive patient-level linkage with several clinical cohorts and national surveillance databases. This allowed analyses which gave important insights into the epidemiology and clinical aspects of HIV drug resistance.

The Database has been overseen by an inclusive Steering Committee and was coordinated by the UCL Institute for Global Health in London. The project was originally funded by the Department of Health and latterly by the UK Medical Research Council (grant 164587).