HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004

TitleHIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004
Publication TypeJournal Article
Year of Publication2008
AuthorsChakraborty R., Smith CJ, Dunn DT, Green H, Duong T., Doerholt K., Riordan A., Lyall H., Tookey P, Butler K., Sabin CA, Gibb DM, Pillay D
JournalPediatr Infect Dis J
Volume27
Pagination457-9
Date PublishedMay
ISBN Number0891-3668 (Print)<br/>0891-3668
Accession Number18382385
KeywordsAdolescent, Adult, Amino Acid Substitution/genetics, Child, Child, Preschool, Cohort Studies, Drug Resistance, Viral/*genetics, Genotype, Great Britain, HIV Infections/*virology, HIV-1/*drug effects/isolation & purification, Humans, Infant, Mutation, Missense
Abstract

We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.

Short TitleThe Pediatric infectious disease journal
Alternate JournalThe Pediatric infectious disease journal