| Title | HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004 |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Chakraborty R., Smith CJ, Dunn DT, Green H, Duong T., Doerholt K., Riordan A., Lyall H., Tookey P, Butler K., Sabin CA, Gibb DM, Pillay D |
| Journal | Pediatr Infect Dis J |
| Volume | 27 |
| Pagination | 457-9 |
| Date Published | May |
| ISBN Number | 0891-3668 (Print)<br/>0891-3668 |
| Accession Number | 18382385 |
| Keywords | Adolescent, Adult, Amino Acid Substitution/genetics, Child, Child, Preschool, Cohort Studies, Drug Resistance, Viral/*genetics, Genotype, Great Britain, HIV Infections/*virology, HIV-1/*drug effects/isolation & purification, Humans, Infant, Mutation, Missense |
| Abstract | We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance. |
| Short Title | The Pediatric infectious disease journal |
| Alternate Journal | The Pediatric infectious disease journal |
