Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe

TitleDeclining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe
Publication TypeJournal Article
Year of Publication2013
AuthorsDe Luca A., Dunn DT, Zazzi M, Camacho R., Torti C., Fanti I., Kaiser R., Sonnerborg A., Codoner F.M, Van Laethem K., Vandamme A.M, Bansi L, Ghisetti V., van de Vijver D.A, Asboe D, Prosperi M.C, Di Giambenedetto S.
JournalJ Infect Dis
Volume207
Pagination1216-20
Date Published2013-04
ISBN Number0022-1899
Accession Number23315324
Keywords*Drug Resistance, Multiple, Viral, Adult, CD4 Lymphocyte Count, Databases, Factual, Europe/epidemiology, Evolution, Molecular, Female, Genotype, HIV Infections/*drug therapy/epidemiology/virology, HIV Protease Inhibitors/pharmacology/therapeutic use, HIV-1/*drug effects/pathogenicity, Humans, Male, Middle Aged, Multivariate Analysis, Mutation, Odds Ratio, pol Gene Products, Human Immunodeficiency Virus/analysis/genetics, Prevalence, Retrospective Studies, Reverse Transcriptase Inhibitors/pharmacology/*therapeutic use, Risk Factors, Sexual Behavior
Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.

Short TitleThe Journal of infectious diseases
Alternate JournalThe Journal of infectious diseases