The UK HIV Drug Resistance Database is a central repository for resistance tests performed as part of routine clinical care throughout the UK. Established in 2001, by the end of 2018 over 150,000 test results, most in the form of viral gene sequences, had been received and curated.

A key feature of the Database is extensive patient-level linkage with several clinical cohorts and national surveillance databases. This has allowed analyses which have given important insights into the epidemiology and clinical aspects of HIV drug resistance.

The Database is overseen by an inclusive Steering Committee and is coordinated by the UCL Institute for Global Health in London. The project was originally funded by the Department of Health and is currently funded by the UK Medical Research Council (grant 164587).